Mae (Chasty Ballesteros) is on the run in Mexico from cartel boss Eduardo Aguilar (Danny Trejo). He wants her dead. But just as his men track her down, four hard-up bounty hunters led by Wade (Luke Goss) swoop in with guns blazing and steal her away. The bounty hunters hole up at a remote hotel south of the border, and the entire place comes under siege by a band of drug runners on the payroll of Aguilar.